“They say that when Colonel Ike Sloan was born, he crawled out of the womb with a knife between his gums. He was the ultimate soldier in his day and the uber-commando template for all Omega Force cyber-soldiers, right down to their combat subroutines which were based on his experience and expertise.”
— Data Console
After consuming Dragon Blood, Col. Sloan's already advanced Mark V cybernetics became "supercharged." Using the research of Dr. Darling and Dr. Carlyle, Sloan weaponized dragon blood into an aerosolized agent that could “make slaves or monsters of men”.
Through an undefined plot, Col. Sloan intends to use this weapon "to redress the balance" in response to peace negotiations between the United States and Russia (referred to as "The Red Menace"), after the nuking of Canada and the invasion of Australia; which were the subsequent results of the Second Vietnam War.
Before their capture, Sgt. Colt and Lt. Brown had thwarted Sloan's first attempt to launch a Red Spear missile armed with the deadly agent. Refusing to become an accomplice to Sloan's plan, Spider was killed, whilst his best friend Colt was forced to watch, setting into motion the events in Far Cry 3: Blood Dragon.
At the end of the game, he is killed by Rex.
Mark IV and V cyborgs have Sloan's combat skills and techniques embedded into their programming.